Vigora 50 mg, which also contains sildenafil citrate, should not be taken with grapefruit juice. The same interaction concerns apply: Enzyme inhibition: Grapefruit juice inhibits CYP3A4, which can increase sildenafil levels in the bloodstream. Increased side effects: Higher levels of sildenafil can lead to more pronounced side effects such as headaches, dizziness, flushing, indigestion, nasal congestion, and vision changes. In rare cases, severe side effects like low blood pressure, fainting, or priapism might occur. https://www.flatmeds.com/product/vigora-50-mg/