Cyclic amino acids are a class of amino acids that contain a cyclic structure in their side chain. These amino acids typically have a different structure compared to the standard amino acids found in proteins.   One example of a cyclic amino acid is proline, which has a five-membered ring structure in its side chain. Proline is unique because its cyclic structure limits the...

What is strain development in microbiology?   Strain development in microbiology refers to the process of modifying microorganisms to enhance their desired traits for various applications. This involves genetic manipulation techniques to introduce specific genetic changes in the microbial genome.   The main objectives of strain development are to improve the production of valuable...

Bioorthogonal reactions, which allow for the efficient and selective labeling of biomolecules in living cells and organisms, are chemical processes that can take place in complex biological systems without interfering with the natural biochemical processes and without significantly toxicating or perturbing the biological system. In the domains of biomedical imaging, pharmaceutical chemistry,...

Most of the ADCs currently in clinical use rely on effective internalization and intracellular lysosome transport to achieve bio-cleavage of linkers to release drugs. And, the cleavaged drug must escape from the lysosome to achieve its therapeutic effect. However, not all tumor antigens can ensure the effective ADC treatment described above, especially in solid tumors. Besides,...

ADC is a complex that conjugates cytotoxic small molecule drugs to monoclonal antibodies through a rationally constructed linker, which can selectively deliver effective cytotoxic drugs into tumors. Currently, the FDA has approved 14 ADC drugs for marketing, and hundreds more are in clinical trials. In addition to overexpression in tumors, another important factor in the selection of ADC drug...

BOC Sciences provides a wide range of research chemicals and biochemicals including inhibitors, building blocks, carbohydrates, nucleosides, nucleotides, GMP Products, impurities and metabolites, APIs, natural compounds, ADCs, stem cell molecule and chiral compounds.   BOC Sciences specializes in small molecules synthesis, biosynthesis, purification and characterization. We have...