Want to know how does cannabinoid receptors work? Cannabinoids, being highly lipid-soluble, were initially thought to act similarly to general anesthetics. The cannabinoid receptors are G protein-coupled receptors activated by endocannabinoids or exogenous agonists such as tetrahydrocannabinol. Upon agonist binding, cannabinoid receptors will activate Gi, inhibiting adenylyl cyclase. Visit...