To ensure the safety and compliance of the chemical supply chain, the following measures can be taken:

1. Understand and Comply with Regulations: Be aware of and adhere to the evolving chemical regulations, such as China's "One Enterprise, One Product, One Code" policy and similar REACH regulations in Asia-Pacific countries. This includes management of hazardous chemicals and compliance obligations for cosmetic ingredients.

2. Inherent Safety Integration: Integrate inherent safety into chemical supply chain optimization through a Mixed Integer Nonlinear Programming (MINLP) based optimization framework that balances process safety and supply chain economics.

3. Multi-Level Mapping and Monitoring: Gain comprehensive understanding of the entire supply network, especially indirect secondary suppliers, as up to 85% of disruptions occur in indirect secondary supply chains. Mapping provides information and visibility to proactively address shortages, find alternatives for non-compliant products, fill gaps, and work with suppliers to resolve other potential issues.

4. Real-Time Monitoring and AI: Invest in tools that provide continuous global risk monitoring, leveraging the predictive analytics capabilities of artificial intelligence to issue real-time alerts, enabling companies to respond immediately to disruptions.

5. Strengthen Supply Chain Security Culture: Establish a positive chemical supply chain security culture that inspires enthusiasm. Create a strong supply chain security management system, culture, and atmosphere through coordination across departments and levels.

6. Improve Supply Chain Transparency and Modernization: Digital transformation is crucial for operational and strategic purposes, increasing the speed of innovation and improving customer transparency through integration.

7. Meet the Challenges of New Markets: Respond agilely to demands, cover global customers, and develop emerging markets.

8. Sustainability: Provide products for a circular economy, reduce overall carbon footprint, and meet local government regulations.

9. Customer-Centric: Meet the needs of flexible supply, reduce lead times to support customer production, and customize supply chain solutions based on demand.

10. Cargo-Based Supply Chain: Provide extensive compliance expertise for dangerous goods, intelligent solutions that consider weight-to-value ratios, and optimize solutions for low-profit products.

By implementing these measures, the safety and compliance of the chemical supply chain can be ensured, while improving efficiency and resilience, reducing costs, and maintaining competitiveness in a competitive market.